产品名称：小鼠核苷酸结合寡聚化结构域样受体蛋白 3 Elisa试剂盒

品牌：Solarbio

产地：北京

样本：血清/血浆/细胞培养上清

应用：Elisa试剂盒

检测方法：双抗体夹心法

检测限：15.6-1000 pg/ml

数量：999

货号：SEKM-0179

用途范围：Mouse

是否进口：否

保存条件：-20

适应物种：Mouse

单 价：2600 元/盒

最小订货量：1盒

供货能力：999

详细描述： NLRP3, also known as NALP3, CIAS1, PYPAF or Cryopyrin, is a cytosolic ~120 kDa member of the NLRP family of proteins expressed in leukocytes, especially neutrophils. As a component of the inflammasome, NLRP3 activates caspases 1 and 5. Defects in NLRP3 may cause FCAS1, CINCA, or Muckle-Wells autoinflammatory syndromes. Mouse NLRP3 contains an N-terminal Pyrin domain (aa 1-91) followed by a Nacht region (aa 216-532), and seven LRRs (aa 739-988). Within the sequence used as an immunogen, mouse NLRP3 shares 78% and 93% aa identity with human and rat NLRP3, respectively. Alternate splicing of mouse NLRP3 generates additional isoforms that lack either LRR2 and 3, LRR 6 and 7, or LRR4-9.